For many vitamins and minerals, persistent megadosing can stress rather than strengthen the body. At More. Longevity & Wellbeing, the focus is always on giving your body the right kind of more: balanced, bioavailable, systems-based nutrition backed by evidence.
Water-Soluble Vitamins (Vitamin C, B-Complex)
• The body uses what it needs and typically excretes the rest, so these are generally safer in excess.
• However, safer is not limitless. Megadoses of Vitamin C (over 2,000 mg per day) may cause kidney stones and digestive issues. Excessive Vitamin B6 can damage nerves.
Fat-Soluble Vitamins (A, D, E, K)
• These are stored in the liver and fatty tissue, so excess can build up and cause toxicity.
• Too much Vitamin A may harm the liver. High Vitamin D levels can cause dangerous calcium buildup.
Expert Guidance
Leading sources such as the NIH and Mayo Clinic consistently caution that more is not always better, unless it is the right nutrient at the right dose for the right person.
Some nutrients, such as Vitamin B12, are safe at higher intakes, particularly for people with absorption issues or genetic variants like MTHFR.
• B12 is water-soluble and has no established upper toxicity limit in clinical guidelines.
• Absorption can be impaired by age, gut conditions, or certain medications. Those affected may require larger, bioavailable doses, ideally under medical guidance.
• Genetic testing for variants such as MTHFR may justify higher methylcobalamin intake, but routine megadosing across healthy populations is not necessary and should be informed by diagnostic evidence.
Clinical Note
Megadose therapy may have a role in medical treatment when prescribed and monitored by clinicians for specific deficiencies. This differs from general consumer supplementation.
Too much of any single mineral can disrupt overall health.
• Zinc overload can deplete copper, creating new deficiencies.
• Excess calcium may interfere with magnesium and iron absorption.
Consensus among nutrition authorities is that supporting synergy, not overload, is the safer approach.
The value and safety of megadosing remain controversial. From orthomolecular medicine to large systematic reviews, the science is still evolving, particularly around chronic disease and long-term outcomes.
• Some practitioners advocate therapeutic megadoses for diagnosed deficiencies.
• Most health organizations including the FDA, NIH, and Cleveland Clinic caution against chronic excess without a clinical need.
• For complex conditions or experimental regimens, expert consultation is essential.
At More. we believe in:
• Synergy over isolation
• Science-backed, safe levels
• Nutrients in bioavailable forms
• Formulas that support multiple systems, including energy, mood, stress, and beyond
Wellness is not about more for the sake of more. It is about the right More, for the right reason.
NIH Dietary Supplement Fact Sheets
Mayo Clinic: Vitamin Supplementation
PubMed Clinical Reviews
FDA Consumer Guidance
For questions about individual needs, consult your healthcare provider or explore our FAQ at More. Longevity & Wellbeing.
This article is for educational purposes only and is not intended as medical advice. Dietary supplement use should be personalized and guided by a qualified healthcare professional. Statements regarding dietary supplements have not been evaluated by the Food and Drug Administration. Products from More. Longevity & Wellbeing are not intended to diagnose, treat, cure, or prevent any disease.
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