At More. Longevity & Wellbeing, we believe supplements should work with your biology, especially when it comes to pathways as foundational as methylation.
MTHFR stands for methylenetetrahydrofolate reductase, an enzyme that helps your body convert folate (vitamin B9) into its active form: 5-methyltetrahydrofolate (5-MTHF).
This conversion is essential for:
• Detoxifying homocysteine, an amino acid linked to inflammation
• DNA synthesis and repair
• Hormone and neurotransmitter metabolism
• Cardiovascular and reproductive health
When the MTHFR gene does not function optimally due to certain genetic variants, your ability to use folate efficiently may be reduced, which can influence multiple systems.
The two most studied variants are:
• C677T
• A1298C
Depending on which variants are present, enzyme activity may be reduced by as much as 70%. Research suggests that 30–60% of people carry one of these variants (Liew & Gupta, 2015; Rai, 2023). Having an MTHFR variant does not automatically mean health problems, but it may increase your need for certain nutrients and attentive lifestyle support.
Only a genetic test can confirm MTHFR status, but some people with methylation challenges report experiences such as:
• Fatigue despite adequate rest
• Mood changes or anxiety
• Sensitivity to supplements, especially folic acid
• Elevated homocysteine levels
• Difficulty detoxing medications or alcohol
• Reproductive or hormonal changes
These symptoms can have many causes, so consultation with a qualified healthcare provider is always recommended for personalized guidance.
Many people with MTHFR variants do not respond well to supplements containing synthetic folic acid or non-methylated forms of B12.
Every More. formula is designed with supportive nutrients in active, bioavailable forms, including:
• Methylfolate (5-MTHF) instead of folic acid
• Methylcobalamin (B12) instead of cyanocobalamin
• Activated B6 and B3 forms
• Synergistic support for detox pathways, hormone balance, and mood stability
Our formulations are designed with methylation support in mind:
• Relax Calming Blend – stress and neurotransmitter balance
• Chill Pill – mood regulation and calm focus
• Vitality Blend – clean energy and hormone support
• Liver Support Blend – detox and inflammation balance
• Menopause Support Blend – transition, hormone, and mood support
• Mocha Mushroom Coffee Superfood Blend – energy and cognition with B vitamins
• Salted Caramel Vanilla Mushroom Coffee Superfood Blend – focus and mood support with B vitamins
• Coconut Banana Mushroom Superfood Blend – gentle energy and gut-brain support without coffee
Our Bone Support Blend is MTHFR-friendly even though it does not include B vitamins. This is because it addresses another key concern: elevated homocysteine from impaired methylation can contribute to arterial calcification.
The blend features:
• Vitamin K2 (MK-7) to direct calcium into bones instead of arteries
• Magnesium, Boron, MCHC Calcium, and Potassium Citrate for mineral balance and density support
Vitamin K2 is often overlooked in bone formulas, yet it plays an essential role in metabolic and cardiovascular balance. Since our other blends already supply methylated B vitamins, we avoid overlapping doses here.
Your genes do not determine your fate, but they can help guide more informed choices. Whether or not you have tested for MTHFR, choosing supplements that support healthy methylation, detoxification, and nutrient bioavailability is a wise step toward long-term wellness.
At More., we design every formula to work with your biology rather than around it. That means no synthetic shortcuts—just clean, synergistic support for real bodies in the real world.
• Liew, S.-C., & Gupta, E. D. (2015). Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases. European Journal of Medical Genetics, 58(1), 1–10.
• Rai, V. (2023). Role of MTHFR C677T gene polymorphism in the development of different diseases. Molecular Biology Reports, 50(1), 1357–1366.
This content is for informational and educational purposes only and is not intended as medical advice. Always consult your healthcare provider before beginning any new supplement routine, especially if you are pregnant, nursing, have a medical condition, or are taking medications.
The statements in this article and on our website have not been evaluated by the Food and Drug Administration. Our products are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.
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Merchandise manufactured in a facility that
complies with good manufacturing practices
